| Player | Team | Att | Yds | Avg | Ypg | Long | TD |
|---|---|---|---|---|---|---|---|
| Donald Buckram | UTEP | 251 | 1569 | 6.3 | 142.6 | 0 | 17 |
| Toby Gerhart | STAN | 282 | 1531 | 5.4 | 139.2 | 0 | 23 |
| Ryan Mathews | FRES | 213 | 1491 | 7.0 | 149.1 | 0 | 14 |
| Mark Ingram | ALA | 205 | 1399 | 6.8 | 127.2 | 0 | 12 |
| Ryan Williams | VT | 244 | 1355 | 5.6 | 123.2 | 0 | 15 |
| Jacquizz Rodgers | ORST | 239 | 1313 | 5.5 | 119.4 | 0 | 19 |
| LaMichael James | ORE | 190 | 1310 | 6.9 | 119.1 | 0 | 11 |
| Bernard Pierce | TEMP | 223 | 1308 | 5.9 | 130.8 | 0 | 15 |
| Dion Lewis | PITT | 224 | 1291 | 5.8 | 129.1 | 0 | 13 |
| Joe Webb | UAB | 209 | 1290 | 6.2 | 117.3 | 0 | 10 |
| Daniel Thomas | KSU | 247 | 1265 | 5.1 | 105.4 | 0 | 11 |
| Anthony Dixon | MSST | 228 | 1258 | 5.5 | 125.8 | 0 | 11 |
| Lance Dunbar | NTEX | 179 | 1252 | 7.0 | 113.8 | 0 | 16 |
| John Clay | WISC | 241 | 1224 | 5.1 | 111.3 | 0 | 13 |
| Montel Harris | BC | 244 | 1213 | 5.0 | 110.3 | 0 | 13 |
| Ben Tate | AUB | 225 | 1209 | 5.4 | 109.9 | 0 | 8 |
| Jonathan Dwyer | GT | 183 | 1203 | 6.6 | 109.4 | 0 | 11 |
| Vai Taua | NEV | 148 | 1185 | 8.0 | 118.5 | 0 | 9 |
| Robert Turbin | UTST | 183 | 1183 | 6.5 | 107.5 | 0 | 10 |
| Brandon West | WMU | 214 | 1164 | 5.4 | 97.0 | 0 | 10 |
| Keith Toston | OKST | 207 | 1130 | 5.5 | 102.7 | 0 | 11 |
| Colin Kaepernick | NEV | 132 | 1129 | 8.6 | 102.6 | 0 | 16 |
| Montario Hardesty | TENN | 225 | 1127 | 5.0 | 102.5 | 0 | 9 |
| Alfred Morris | FAU | 213 | 1112 | 5.2 | 111.2 | 0 | 9 |
| Evan Royster | PSU | 188 | 1104 | 5.9 | 92.0 | 0 | 6 |
| Noel Devine | WVU | 192 | 1098 | 5.7 | 109.8 | 0 | 10 |
| Frank Goodin | LAMO | 206 | 1086 | 5.3 | 98.7 | 0 | 13 |
| Alexander Robinson | ISU | 210 | 1058 | 5.0 | 96.2 | 0 | 6 |
| Roy Helu | NEB | 193 | 1057 | 5.5 | 96.1 | 0 | 10 |
| Darius Marshall | MARS | 207 | 1054 | 5.1 | 117.1 | 0 | 11 |
| Luke Lippincott | NEV | 133 | 1028 | 7.7 | 102.8 | 0 | 9 |
| Jeremy Avery | BSU | 167 | 1008 | 6.0 | 91.6 | 0 | 5 |
| Curtis Steele | MEM | 179 | 1007 | 5.6 | 111.9 | 0 | 11 |
| Shawnbrey McNeal | SMU | 198 | 978 | 4.9 | 88.9 | 0 | 7 |
| Jordan Todman | CONN | 185 | 956 | 5.2 | 95.6 | 0 | 13 |
| Brynn Harvey | UCF | 224 | 947 | 4.2 | 94.7 | 0 | 13 |
| Ralph Bolden | PUR | 200 | 935 | 4.7 | 77.9 | 0 | 9 |
| Daniel Porter | LATC | 183 | 933 | 5.1 | 84.8 | 0 | 8 |
| Joe McKnight | USC | 143 | 932 | 6.5 | 93.2 | 0 | 8 |
| Delone Carter | SYR | 216 | 919 | 4.3 | 83.5 | 0 | 10 |
| Eddie Wide | UTAH | 161 | 918 | 5.7 | 83.5 | 0 | 11 |
| DaJuane Collins | TOL | 161 | 917 | 5.7 | 83.4 | 0 | 12 |
| Andre Anderson | TUL | 211 | 911 | 4.3 | 82.8 | 0 | 7 |
| Dexter McCluster | MISS | 131 | 903 | 6.9 | 90.3 | 0 | 6 |
| Harvey Unga | BYU | 161 | 900 | 5.6 | 90.0 | 0 | 9 |
| C.J. Spiller | CLEM | 172 | 894 | 5.2 | 81.3 | 0 | 7 |
| Chris Polk | WASH | 179 | 889 | 5.0 | 88.9 | 0 | 3 |
| Damion Fletcher | USM | 189 | 877 | 4.6 | 87.7 | 0 | 8 |
| MiQuale Lewis | BALL | 181 | 871 | 4.8 | 72.6 | 0 | 5 |
| Jahvid Best | CAL | 141 | 867 | 6.1 | 96.3 | 0 | 12 |
