October 24, 2009
| First Quarter | TUL | USM | |||
| USM | TD | 5:25 | DeAndre Brown 21 yd pass from Martevious Young (Justin Estes kick) | 0 | 7 |
| Second Quarter | TUL | USM | |||
| USM | TD | 6:16 | Jamie Collins 16 yd fumble return (Justin Estes kick) | 0 | 14 |
| USM | TD | 0:38 | Andre Watson 77 yd blocked FG return (missed kick) | 0 | 20 |
| Third Quarter | TUL | USM | |||
| USM | TD | 8:43 | DeAndre Brown 6 yd pass from Martevious Young (missed kick) | 0 | 26 |
| TUL | TD | 2:41 | Andre Anderson 1 yd run (missed kick) | 6 | 26 |
| Fourth Quarter | TUL | USM | |||
| USM | FG | 13:40 | Justin Estes 24 yd FG | 6 | 29 |
| USM | TD | 5:53 | Tory Harrison 4 yd run (Justin Estes kick) | 6 | 36 |
| USM | TD | 1:31 | Tracey Lampley 2 yd run (Justin Estes kick) | 6 | 43 |
HATTIESBURG, Miss.(AP) DeAndre Brown caught a pair of touchdown passes as Southern Mississippi rolled over Tulane 43-6 on Saturday night.
Southern Miss quarterback Martevious Young made his third start his most consistent, going 13 of 15 for 127 yards with touchdown passes of 21 and 6 yards to Brown, who had four catches for 41 yards.
Green Wave quarterback Ryan Griffin was sacked six times and fumbled twice in his debut as a starter.
Jamie Collins scooped up one of Griffin's fumbles and returned it 15 yards for a touchdown in the second quarter and Andre Watson returned a blocked field goal 75 yards for another score.
Tory Harrison led Southern Miss (5-3, 3-1 Conference USA) with 93 yards and a touchdown on 14 carries.
The Golden Eagles held Tulane (2-5, 0-4) to 208 yards of offense.
Andre Anderson rushed for 92 yards and scored Tulane's lone touchdown in the third quarter.